ABSTRACT
Decrease fibrinolytic response after infusion of 1-deamino-8-D-arginine vasopressin (DDAVP) was reported in patients with von Willebrand disease (vW) (Nouv. Rev. Fr.Hematol.1992, 34:55-60), suggesting an association between vW factor and syntesis or/and realese of t-PA by endothelial cells. In the present study we measured the activity of plasmatic euglobulin fractions by fibrin plate method in 65 patients with hemostatic disorders: 36 vW type I, 9 hemophilics A (HA), 6 storage pool disease (SPD), 6 primary hemostasis alteration (PHA), 8 PHA and decrease factor VIII (PHAH), and 5 normals (N). DDAVP was administrated intravenously at 0,4 ug/Kg body weight. The means SD (mm) of the difference between the diameter of lysis area from the highest and basal response were: N 4,60ñ1,55; vWd 6,38ñ2,77; HA 4,77ñ2,95; SPD 4,9ñ1,69; PHA 5,63ñ4,3:PHAH 4,35ñ2.09. No statistical difference was obtained between N and patients. A higher than normal fibrinolytic response was observed in vW 12/365, HA 2/9, PHA 2/6, PHAH 2/8. A decrease response was showed by vWd 0/36, HA 1/9, SPD 0/6, and PHAH 0/8. Our observation suggest that the FvW is not related with the plasmatic fibrinolytic activity